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Over 99% of investigational drugs, participating in over 200 clinical trials, failed to receive approval for the treatment of Alzheimers disease [1]

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doi:10.1101/cshperspect.a009183 Acknowledgments This work was supported by the Chang Gung Memorial Hospital [Grants CMRPD1A0531, CMRPD1C0231, CMRPG391311, CMRPG3A1131] and the Ministry of Science and Technology, Taiwan [Grant NMRPD181001-3]

At the vascular and interstitial scale, insufficient perfusion and dense stromal architecture limit the ability of nanocarriers to enter tumor tissue and access deeper regions, making enhancement of functional perfusion and penetration a primary design concern [31, 33, 36]